Mechanism of Action

Barostim is Designed to Restore Sympathovagal Balance

Barostim Reduces Muscle Sympathetic Activity in Studies

Barostim Increases Parasympathetic Tone in Studies

The Baroreflex:

Master Regulator of Blood Flow

The brain interprets baroreceptor stimulation as a rise in blood pressure.

It responds by inhibiting sympathetic drive and enhancing parasympathetic tone.

Improved sympatho-vagal balance reduces heart rate, dilates arteries and reduces fluid volume

These physiological events establish a new circulatory homeostatic equilibrium characterized by:

lower blood pressure
lower myocardial work
lower oxygen consumption

Heusser et al showed that muscle sympathetic activity (MSNA) falls and rises in tandem with blood pressure as Barostim is turned ON and OFF. (To see abstract click here)

Wustmann et al showed that heart rate variability and the LF:HF ratio improve, consistent with improved vagal tone and reduced sympathetic drive. (To see abstract click here)