CVRx®, Inc. Closes $29.6 Million Financing

Minneapolis – July 10, 2013 – CVRx, Inc., a private medical device company, has
completed a private equity financing totaling $29.6 million.

CVRx plans to use the funding for the primary purposes of advancing its clinical trials and
expanding its international commercial activities. New Enterprise Associates, Inc. (NEA)
and Johnson & Johnson Development Corporation were the co-lead investors. Other
participants in this round included existing investors BBT Fund L.P. and SightLine

About the Co-Lead Investors

NEA, founded in 1978, is a leading venture capital firm focused on helping entrepreneurs
create and build major new enterprises. NEA focuses on investments at all stages of a
company’s development, from seed stage through IPO. With approximately $13 billion in
committed capital across its affiliated funds, NEA’s experienced management team has
invested in over 600 companies. For additional information, visit

Organized in 1973, Johnson & Johnson Development Corporation (JJDC) is the venture
capital subsidiary of Johnson & Johnson. JJDC makes private equity investments in
venture funded health care companies. Portfolio companies include those in the fields of
pharmaceuticals, biotechnology, medical devices, diagnostics and consumer products.
For more information, go to

About CVRx, Inc.

CVRx, Inc. is a privately held company founded in 2001 and headquartered in
Minneapolis. The company has developed the Barostim neo™, an implantable system
designed to treat hypertension and heart failure. Barostim neo received CE marking for
the treatment of hypertension in Europe. It is under clinical evaluation for the treatment of
heart failure in Europe and the United States and under clinical evaluation for the
treatment of hypertension in the United States. CVRx has treated more than 625 patients
with its patented devices.

About Heart Failure

In heart failure, heart function is impaired, resulting in shortness of breath, exercise
intolerance and fluid retention. In the United States, heart failure is estimated to affect 5.1
million adults.1 Overall, heart failure is associated with a four-fold increased risk of death
and a six to nine times increased risk of sudden cardiac death.1 The direct and indirect
costs of heart failure are estimated to be $32 billion in the United States in 2013.1

About Hypertension

In the United States, hypertension affects 77.9 million people.1 Worldwide, hypertension
is estimated to cause one in every eight deaths.1 It is a major risk factor for
cardiovascular disease, morbidity and mortality. Twenty-five percent of people with
hypertension cannot adequately control their hypertension with medications and lifestyle
modifications.2,3 It is a disease that needs new treatment solutions.

About Barostim neo

Barostim neo is a second generation device that uses CVRx-patented technology that is
designed to trigger the body’s own natural blood flow regulation system to treat
hypertension and heart failure. The system works by electrically activating the
baroreceptors, the body’s natural blood pressure sensors that regulate cardiovascular
function. These baroreceptors are located on the carotid artery. When activated by
Barostim neo, signals are sent through neural pathways to the brain, which responds by
telling the:

  • Arteries to relax, making it easier for blood to flow through the body and reducing cardiac exertion;
  • Heart to slow down, allowing more time for the organ to fill with blood; and
  • Kidneys to reduce fluid in the body, lowering both excessive blood pressure and workload on the heart.

This unique, patented technology has the potential to improve quality of life and reduce
health risks associated with hypertension and heart failure, including heart and kidney
disease, stroke and death. Other key potential benefits of Barostim neo include the

  • Can be adjusted to meet each patient’s individual therapy needs, making it the only personalized medical device therapy for the treatment of hypertension with a CE marking;
  • Is a non-destructive reversible treatment; and
  • Provides 100% compliance to treatment, by automatically and continuously activating the baroreflex.

CVRx Contacts:
John Brintnall
Chief Financial Officer
Phone: 763.416.2853

Rebecca Olson
Corporate Communications
Phone: 763.416.2355

1. Heart Disease and Stroke Statistics. American Heart Association – 2013 Update.
Circulation 2013;127:e6-e245.
2. Prospective Studies Collaboration. Lancet 2002;360:1903-1913.
3. Chobanian AV. JAMA 2003;289:2560-2572.

CAUTION: Barostim neo is an investigational device and is limited by United States law to
investigational use. Exclusively for Clinical Investigations for the treatment of heart failure (in the
European Union and Canada).

CVRx, Barostim neo and Barostim Therapy are trademarks of CVRx, Inc. registered in the United
States Trademark Office.

© CVRx, Inc. 2013. All rights reserved.